LENVIMA® (lenvatinib) is used by itself as the first treatment for a type of liver cancer called hepatocellular carcinoma (HCC) when it cannot be removed by surgery.
Differentiated thyroid 
Advanced kidney cancer (RCC) Advanced kidney cancer (RCC) 
Inoperable liver cancer (HCC)
Advanced endometrial cancer*
*Taken in combination with pembrolizumab.
†Taken in combination with everolimus after one course of treatment with another anti-cancer medicine.
Inoperable liver cancer (HCC)
How to take LENVIMA
LENVIMA is an oral medication, taken once a day at the same time, with or without food.
Your doctor will tell you how much LENVIMA to take and when to take it. Your doctor may choose to adjust your dose, stop treatment for some time, or completely stop treatment with LENVIMA if you have side effects.
Capsules not actual size.
Your daily dose of LENVIMA for inoperable liver cancer is based on your body weight. Your dose may be either two or three 4-mg capsules
Your health care provider will tell you how much LENVIMA to take and when to take it
Your health care provider may choose to adjust your dose, stop treatment for some time, or completely stop treatment with LENVIMA if you have side effects
Your health care provider will tell you how much LENVIMA to take and when to take it.
Your health care provider may also adjust your dose during treatment, stop treatment for some time, or completely stop treatment with LENVIMA if you have side effects.
These are 2 examples of the LENVIMA blister card. The card your doctor prescribed may look different than these.
LENVIMA capsules come in color-coded cards that contain medicine for 5 days. The number of capsules you need to take may vary, depending on your prescription.
You should take LENVIMA without interruption, unless otherwise instructed by your health care provider. There are 6 cards in each carton, which adds up to a 30-day supply of LENVIMA.
Step 1:
Place your daily dose, up to 5 capsules, in a small container or oral syringe (approximately 20mL capacity).
Step 2:
Add 3 mL of water or apple juice to the container or oral syringe. Wait 10 minutes for the capsule shell (outer surface) to dissolve completely, then stir or shake the mixture for 3 minutes until capsules are fully dissolved. Do not break or crush the capsules.
Step 3:
Drink the liquid mixture or use an oral syringe to take directly into the mouth.
Step 4:
Next, using a second syringe, add an additional 2 mL of liquid to the other container or oral syringe (cap the first oral syringe before adding the additional water) then swirl or shake and take the liquid mixture. Repeat this step at least one time and until you cannot see any of the LENVIMA mixture left in the container or oral syringe to make sure all of the medicine is taken.
Note:
If 6 capsules are required for your daily dose, follow the above instructions using 3 capsules at a time.
Storage:
LENVIMA mixture may be stored in a covered container in the refrigerator at 36°F to 46°F (2°C to 8°C) for a maximum of 24 hours. Throw away the LENVIMA mixture if not used within 24 hours of mixing.
LENVIMA should be given in feeding tubes of at least 5 french diameter (polyvinyl chloride or polyurethane tube) and at least 6 French diameter (silicone tube).
Step 1:
Place your daily dose, up to 5 capsules, in a syringe (approximately 20 mL capacity).
Step 2:
Add 3 mL of water to the syringe. Wait 10 minutes for the capsule shell (outer surface) to dissolve completely, then stir or shake the mixture for 3 minutes until capsules are fully dissolved. Do not break or crush the capsules.
Step 3:
Give the mixture through a feeding tube.
Step 4:
Next, cap the syringe and remove the plunger. Use a second syringe and add an additional 2mL of liquid to the syringe. Swirl or shake and give the mixture in the feeding tube. Repeat this step at least one time and until you cannot see any of the LENVIMA mixture left in the syringe to make sure all of the medicine is taken.
Note:
If 6 capsules are required for your daily dose, follow the above instructions using 3 capsules at a time.
Storage:
LENVIMA mixture may be stored in a covered container in the refrigerator at 36°F to 46°F (2°C to 8°C) for a maximum of 24 hours. Throw away the LENVIMA mixture if not used within 24 hours of mixing.
Call your health care provider or go to the nearest hospital
emergency room right away.
Be sure to store LENVIMA in a room with steady temperature.
Do not use LENVIMA for a condition for which it was not prescribed. Do not give LENVIMA to other people, even if they have the same symptoms you have. It may harm them. You can ask your health care provider or pharmacist for information about LENVIMA that is written for health care professionals.
Find information about how LENVIMA may work, how it is taken, tips for managing treatment, and more.
Financial assistance programs are
available to help appropriate
patients access LENVIMA.
